Prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (March 2012).
JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW,
Interspecies divergence of 3' non-coding regions". "Complementary DNA sequence of a human cytoplasmic actin. Hanukoglu I, Tanese N, Fuchs E (February 1983). The amino terminus of the protein, but the functional significance of this remains unknown. A preponderance of ACTB mutations was also noted (based on evolutionary conservation and the nature of the observed amino acid change), the predicted functionalĬonsequence of the ACTB mutations observed in DLBCL is high.
Actins areĬonserved proteins of the cytoskeleton and are involved in B lymphocyte activation. Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma. Variants between the EV71-susceptible RD cells and EV71-resistant RD cells, suggesting that beta-actin, inĪssociation with other proteins such as annexin 2 is required in vesicular transport of EV71. EV71 is endemic in theĪsia-Pacific region and causes occasional epidemics.Significant differences have been found in the beta-actin Enterovirus 71 (EV71) is one of the mainĪgents of the Hand, Foot and Mouth Disease (HFMD) and has been known to cause fatal neurological complicationsĪs herpangina, aseptic meningitis, poliomyelitis-like paralysis and encephalitis. Beta-Actin and Diseasesīeta-actin variant is necessary for Enterovirus 71 replication. The molecular weight (MW) of beta-actin is approximately 42 kD. This actin is a major constituent of the contractile apparatus and one of Actins are highly conserved proteins that are involved in cell It is also known as BRWS1 or PS1TP5BP1.ThisĮncodes one of six different actin proteins. The official symbol of beta-actin gene is ACTB (provided by HGNC). (HepG2: human HeLa: human SVT2: mouse A549: human COS7: monkey Jurkat: human MDCK: canine PC12: rat Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-beta-actin monoclonal OriGene offers high quality quality of Anti-beta actin Beta-Actin Western Blotīeta-actin, is usually used as a loading control for Western Blot to normalize the levels of protein detected byĬonfirming that protein loading is the same across the gel. Beta-actinĪ major constituent of the contractile apparatus. These amino acid differences confer different biochemical properties between the two isoforms. In striated and smooth muscle cells, whereas beta-actin and gamma-actin isoforms are ubiquitously expressed.Ĭonserved from birds to mammals, beta-actin and gamma-actin differ at only four biochemically similar amino acid Actins are highly conserved proteins that are involved in cell motility, structure, and integrity.Īre six different but highly conserved actin isoforms in vertebrates. Protein detected by confirming that protein loading is the same across the gel. They can be used to normalize the levels of Beta-actin Loading Control Beta-Actin Proteinīeta-actin, also known as a "housekeeping" protein, is usually used as a loadingĬontrol, for among others, the integrity of cells, protein degradation, in PCR and Western blotting.Ĭontrols are essential for proper interpretation of western blots.
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